COVID-19 vakalarında DNA hasarı ve enflamasyon

Purpose: The aim of this study is to see oxidative DNA damage (8-OHdG), its relationship with inflammatory mediators (IL6 and TNFA), reflections on laboratory findings in patients who had COVID-19 infection at different intensities.
 Materials Methods: Serum interleukin-6 (IL6), tumor necrosis factor-alpha (TNFA), 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels were measured using kits based the enzyme-linked immunosorbent assay (ELISA) principle.
 Results: In positive treated intensive care 8-OHdG marker level highest statistically significant. receiving inpatient treatment hospitalized, higher than control outpatient groups. IL6 values patient group unit There was no significant difference between groups terms TNFA values. Neutrophil-to-lymphocyte ratio (NLR) lower all C-reactive protein (CRP) hospitalized group. Lactate dehydrogenase (LDH) found be significantly outpatients.
 Conclusion: As severity increases, serum also increase. These parameters can guide diagnosis early stages disease course.